Faculty Profile

Andrew M Smith

Bioengineering
Andrew M Smith
Andrew M Smith
Assistant Professor
  • Bioengineering
  • Materials Science and Engineering
  • Micro and Nanotechnology Laboratory
3114 Micro and Nanotechnology Lab
208 N. Wright Street
Urbana Illinois 61801
(217) 300-5638

Affiliation

  • Bioengineering
  • Materials Science and Engineering
  • Micro and Nanotechnology Laboratory

Primary Research Area

  • Bio-Micro and Nanotechnology

Education

  • Ph.D. Bioengineering, Georgia Institute of Technology
  • B.S. Chemistry, Georgia Institute of Technology

Academic Positions

  • Associate Head of Undergraduate Programs, Department of Bioengineering, 2016-Present
  • Full-Time Resident Faculty, Micro and Nanotechnology Laboratory (MNTL), 2013-Present
  • Affiliate Faculty, Department of Materials Science and Engineering, 2013-Present
  • Assistant Professor, University of Illinois at Urbana-Champaign, Department of Bioengineering, 2012-Present
  • Postdoctoral Fellow, Emory University, 2008-2012

For more information

Research Interests

  • Obesity comorbidities
  • Live-cell imaging
  • Intravital microscopy
  • Single-molecule imaging
  • Cancer biology
  • Quantum dot chemistry and physics
  • Nanomaterials

Research Areas

  • Cancer biology
  • Intravital microscopy
  • Live-cell imaging
  • Nanomaterials
  • Nanoparticle bioimaging probes
  • Quantum dot chemistry and physics
  • Single-molecule imaging

Research Topics

  • Bio-Micro and Nanotechnology
  • Bioimaging at Multi-Scale

Chapters in Books

  • Ma L, Le P, Kohli M, and Smith AM. Introduction to nanotechnology and medicine, chapter in Nanotheranostics for Cancer Applications, Springer (invited chapter).
  • Zahid MU and Smith AM. Single molecule imaging with quantum dots, chapter in Optical Nanoscopy and Novel Microscopy Techniques, CRC Press (2014).
  • Smith AM, Wen MW, Wang MD, Nie SM. Size-minimized quantum dots for molecular and cellular imaging, chapter in Single Molecule Spectroscopy in Chemistry, Physics, and Biology: Nobel Symposium, Springer (2009).
  • Rhyner MN, Smith AM, Gao XH, Mao H, Lily L, Nie SM. Quantum dots and targeted nanoparticle probes for in-vivo tumor imaging, chapter in Nanoparticles in Biomedical Imaging, Springer (2007).
  • Ruan G, Agrawal A, Smith AM, Gao XH, Nie SM. Quantum dots as fluorescent labels for molecular and cellular imaging, chapter in Reviews in Fluorescence, Springer (2006).
  • Smith AM and Nie SM. Semiconductor quantum dots for molecular and cellular imaging, chapter in The Biomedical Engineering Handbook, 3rd edition, CRC Press (2006).

Selected Articles in Journals

  • Mukherjee P, Lim SJ, Wrobel T, Bhargava R, and Smith AM. Spectroscopic determination of the internal structure of nanocrystals (submitted).
  • Wan Y., Carson JA, Kesler BA, Peng W, Su P, Al-Mulla SA, Lim SJ, Smith AM, Dallesasse JM, and Cunningham AM. Compact characterization of liquid absorption and emission spectra using linear variable filters integrated with a CMOS imaging camera (submitted).
  • Ma L, Liu T-W, Wallig MA, Dobrucki IT, Dobrucki LW, Nelson ER, Swanson KW, and Smith AM. Efficient targeting of adipose tissue macrophages in obesity (submitted).
  • Lim SJ, Ma L, Schleife A, and Smith AM. The impact of surfaces and ligands on the optical properties of quantum dots. (accepted, invited article for Coordination Chemistry Reviews).
  • Le P, Chitoor SN, and Smith AM. Molecular profiling of single cells with quantum dots. (accepted, invited article for Methods in Molecular Biology).
  • Ma L, Tu C, Le P, Chitoor SN, Lim SJ, Zahid MU, Teng KW, Ge P, Selvin PR, and Smith AM. Multidentate polymer coatings for compact and homogeneous quantum dots with efficient bioconjugation. Journal of the American Chemical Society, 138: 3382-3394 (2016).
  • Lim SJ, McDougle DR, Zahid MU, Das A, and Smith AM. Lipoprotein nanoplatelets: fluorescent, zwitterionic probes for molecular and cellular imaging. Journal of the American Chemical Society, 138: 64-67 (2016).
  • Grolman JM, Zhang D, Smith AM, Moore JS, and Kilian KA. Rapid extrusion of 3D tumor microenvironments. Advanced Materials, 27: 5512-5517 (2015).
  • Chung EY, Ochs CJ, Wang Y, Lei L, Smith AM, Strongin AY, Lu SY, Kamm R, and Wang YX. Activatable, cell-penetrating quantum dot nanosensor for visualizing MT1-MMP activity in single cancer cells. Nano Letters, 15: 5025-5032 (2015).
  • Lim SJ, Zahid MU, Le P, Ma L, Entenberg D, Harney AS, Condeelis J, and Smith AM. Brightness-equalized quantum dots. Nature Communications. 6: 8210 (2015).
  • Dobrucki W, Pan D, and Smith AM. Multiscale imaging of nanoparticle drug delivery. Current Drug Targets, 16: 560-570 (2015).
  • Lane LA, Qian XM, Smith AM, and Nie SM. The physical chemistry of nanomedicine: Nanoparticle interactions with molecules, cells, and tissues. Annual Review of Physical Chemistry, 66: 521-547 (2015).
  • Wang Y, Cai E, Rosenkranz T, Ge P, Teng K, Lim SJ, Smith AM, Chung H, Sachs F, Green W, Gottlieb P, and Selvin PR. Small Quantum Dots Conjugated to Nanobodies as Immunofluorescence Probes for Nanometric Microscopy. Bioconjugate Chemistry. 25: 2205-2211 (2014).
  • Lane LA, Smith AM, and Nie SM. Compact and blinking-suppressed quantum dots for biological imaging. Journal of Physical Chemistry B. 118: 14140-14147 (2014).
  • Cai E, Ge P, Lee SH, Jeyifous O, Wang Y, Liu Y, Wilson KM, Lim SJ, Baird MA, Stone JE, Lee KY, Fernig DG, Davidson MW, Chung HJ, Schulten K, Smith AM, Green WN, and Selvin PR. Stable small quantum dots for synaptic receptor tracking on live neurons. Angewandte Chemie, International Edition. 53: 12484-12488 (2014).
  • Smith AM, Lane LA, and Nie SM. Mapping the distribution of charge carriers in semiconductor heterostructures. Nature Communications. 5: 4506 (2014).
  • Lim SJ, Smith AM, and Nie SM. The more exotic shapes of semiconductor nanocrystals: emerging applications in bioimaging. Current Opinion in Chemical Engineering. 4: 137-143 (2014).
  • Ma L, Kohli M, and Smith AM. Nanoparticles for combination drug therapy. ACS Nano, 7: 9518-9525 (2013).
  • Kairdolf BA, Smith AM, Stokes TD, Wang MD, Young AN, and Nie SM. Semiconductor quantum dots for bioimaging and biodiagnostic applications. Annual Review of Analytical Chemistry. 6: 143 (2013).
  • Smith AM and Nie SM. Compact quantum dots for single-molecule imaging. Invited article for Journal of Visualized Experiments, 68: e4236 (2012).
  • Smith AM and Nie SM. Bright and compact alloyed quantum dots with broadly tunable near-infrared absorption and fluorescence spectra through mercury cation exchange, Journal of the American Chemical Society, 133: 24-26 (2011).
  • Smith AM, Wen MM, and Nie SM. Imaging dynamic cellular events with quantum dots. The Biochemist, 32:12-17 (2010).
  • Smith AM and Nie SM. Semiconductor nanocrystals: structure, properties, and bandgap engineering. Accounts of Chemical Research, 43: 190-200 (2010).
  • Smith AM, Mancini MC, Nie SM. Bioimaging: second window for in vivo imaging, News and Views article in Nature Nanotechnology, 4: 710-711 (2009).
  • Smith AM and Nie SM. Next-generation quantum dots, News and Views article in Nature Biotechnology, 27: 732-733 (2009).
  • Mohs AM, Duan, HW, Kairdolf BA, Smith AM, Nie SM. Proton-resistant quantum dots: stability in gastrointestinal fluids and implications for oral delivery of nanoparticle agents. Nano Research, 2: 500-509 (2009).
  • Smith AM, Mohs AM, Nie SM. Tuning the electronic and optical properties of quantum dots by lattice strain. Nature Nanotechnology, 4: 56-63 (2009).
  • Smith AM, Nie SM. Nanocrystal synthesis in an amphibious bath: spontaneous generation of hydrophilic and hydrophobic surface coatings. Angewandte Chemie International Edition, 47: 9916-9921 (2008).
  • Kairdolf BA, Smith AM, Nie SM. One-pot synthesis, encapsulation, and solubilization of size-tuned quantum dots with amphiphilic multidentate ligands. Journal of the American Chemical Society, 130: 12866-12867 (2008).
  • Smith AM, Nie SM. Minimizing the hydrodynamic size of quantum dots with multifunctional multidentate polymer ligands. Journal of the American Chemical Society, 130: 11278-11279 (2008).
  • Mancini MC, Kairdolf BA, Smith AM, Nie SM. Oxidative quenching and degradation of polymer encapsulated quantum dots: new insights into the long term fate of semiconductor nanocrystals in vivo. Journal of the American Chemical Society, 130: 10836-10837 (2008).
  • Smith AM, Duan HW, Mohs AM, Nie SM. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Advanced Drug Delivery Reviews, 60: 1226-1240 (2008).
  • Kairdolf BA, Mancini MC, Smith AM, Nie SM. Minimizing nonspecific cellular binding of quantum dots with hydroxyl-derivitized surface coatings. Analytical Chemistry, 80: 3029 (2008).
  • Xing Y, Smith AM, Agrawal A, Ruan G, Nie SM. Molecular profiling of single cancer cells and clinical tissue specimens with semiconductor quantum dots. International Journal of Nanomedicine, 1: 473-481 (2006).
  • Smith AM, Duan HW, Rhyner MN, Ruan G, Nie SM. A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots. Physical Chemistry Chemical Physics, 8: 3895-3903 (2006).
  • Rhyner MN, Smith AM, Gao XH, Mao H, Yang L, Nie SM. Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. Nanomedicine, 1: 209-217 (2006).
  • Smith AM, Dave S, Nie SM, True L, Gao XH. Multicolor quantum dots for molecular diagnostics of cancer. Expert Review of Molecular Diagnostics, 6: 231-244 (2006).
  • Smith AM, Ruan G, Rhyner MN, Nie SM. Engineering luminescent quantum dots for in vivo molecular and cellular imaging. Annals of Biomedical Engineering, 34: 3-14 (2006).
  • Smith AM, Gao XH, Nie SM. Quantum dot nanocrystals for in vivo molecular and cellular imaging. Photochemistry and Photobiology, 80: 377-385 (2004). [Cover article]
  • Bailey RE, Smith AM, Nie SM. Quantum dots in biology and medicine. Physica E, 25: 1-12 (2004).
  • Smith AM, Nie SM. Chemical analysis and cellular imaging with quantum dots. Analyst, 129: 672-677 (2004). [Cover article]

Honors

  • IEEE EMBS Micro and Nanotechnology in Medicine Conference New Innovators Lectureship (2014)
  • NCI K99/R00 Pathway to Independence Award (2010-2015)
  • Emory University Center for Cancer Nanotechnology Excellence Distinguished Fellowship (2008-2012)
  • Whitaker Foundation Graduate Research Fellowship (2002-2006)
  • NSF Undergraduate Research Scholarship (2000-2002)
  • Lubrizol Scholarship for Excellence in Chemistry (2002)
  • Outstanding Rising Junior in Computer Science (1999)

Research Honors

  • Annals of Biomedical Engineering 2006 Best Review Paper of the Year (2007)
  • Outstanding Poster Award, Emory-Georgia Tech Frontiers of Cancer Nanotechnology Symposium (2006)
  • Photochemistry and Photobiology 2004 Best Review Paper of the Year (2005)
  • Biomedical Engineering Society Undergraduate Research Award (2001)